Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. jjoseph16@partners.org. Department of Medicine, VA Boston Healthcare System, Boston, MA, USA. jjoseph16@partners.org. Duke Clinical Research Institute, Durham, NC, USA. Department of Oncology, Georgetown University School of Medicine, Washington, DC, USA. Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.